Observe Carefully (one)belzutifan will lessen the extent or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
diazepam will boost the amount or influence of atogepant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
teduglutide raises amounts of diazepam by Other (see remark). Use Warning/Check. Comment: Teduglutide may well increase absorption of concomitant PO prescription drugs; caution with with medications requiring titration or Individuals by using a slender therapeutic index; dose adjustment may very well be essential.
four.six Fertility, pregnancy and lactation Pregnancy Paracetamol: A large amount of facts on Expecting women suggest neither malformative, nor feto/neonatal toxicity. Epidemiological research on neurodevelopment in young children subjected to paracetamol in utero show inconclusive final results.
This compound belongs to The category of natural compounds often called morphinans. They're polycyclic compounds with a 4-ring skeleton with a few condensed 6-member rings forming a partly hydrogenated phenanthrene moiety, certainly one of and that is aromatic while The 2 Some others are alicyclic.
lemborexant, diazepam. Possibly increases outcomes of another by sedation. Modify Therapy/Keep an eye on Intently. Dosage adjustment could be vital if lemborexant is coadministered with other CNS depressants due to the fact of potentially additive results.
Liquor needs to be prevented. When dihydrocodeine is prescribed for Persistent use, treatment need to be taken to stay away from avoidable increase in dosage.
griseofulvin will lower the extent or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
diazepam will raise the degree or impact of lemborexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Decrease nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. See drug monograph for distinct dosage modification.
PL numbers are stated underneath Every single merchandise on this website. To discover your medication’s PL selection, appear about the carton or bottle label, as this will likely have the PL quantity on it (normally about the again – Look at beneath the dispensing label if vital).
dronedarone will raise the amount or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Monitor Closely (1)enasidenib will boost the level or influence of diazepam by impacting hepatic enzyme CYP2C19 metabolism.
lemborexant, diazepam. get more info Either increases effects of one other by sedation. Modify Therapy/Watch Carefully. Dosage adjustment could possibly be needed if lemborexant is coadministered with other CNS depressants due to the fact of potentially additive consequences.
Sedative medicines which include benzodiazepines or linked medicines: The concomitant usage of opioids with sedative medicines including benzodiazepines or similar medications increases the possibility of sedation, respiratory depression, coma and Loss of life thanks to additive CNS depressant impact. The dose and length of concomitant use should be restricted (see part 4.4).